From Prion to Botulinum Neurotoxin (BoNT) ... NeuroMedicine vs. NeuroDegenerative Disease

Normal Prion Protein is capable of binding several divalent cations such as Cu2+ and Zn2+. The newest cytological evidences suggest it may be related to the homeostasis of cellular metallo-proteins through endocytosis. The discovery linked the biochemical behavior & structural feature of normal prion to botulinum neurotoxin. Nature is really amazing!